What Are PFAS? Understanding Risk, Regulation, and Safety Differences

Ask GIA™ Blog

Glove Intelligent Assistant
04.15.2026

Using the TF-95RB in a laboratory

PFAS (per- and polyfluoroalkyl substances) are a group of over 15,000 synthetic chemicals used for their resistance to heat, water, and oil. While some PFAS are associated with environmental and health concerns, others—such as fluoropolymers—are widely used in regulated applications due to their stability and safety profile.

In April 2024, the U.S. Environmental Protection Agency (EPA) established enforceable Maximum Contaminant Levels (MCLs) for six PFAS chemicals under the National Primary Drinking Water Regulation.3

Per- and polyfluoroalkyl substances (PFAS) have been used across industrial and consumer applications since the 1940s. Their defining characteristic—strong carbon-fluorine bonds—makes them highly resistant to heat, water, and oil, but also highly persistent in the environment.

PFAS can be found in a wide range of applications, including firefighting foams, manufacturing processes, food packaging, and consumer products. As regulatory scrutiny increases, PFAS are often discussed as a single category of concern—but that simplification misses a critical point.

Not All PFAS Are the Same

Not all PFAS present the same level of risk. Differences in molecular size, structure, and mobility determine how these substances behave in the environment and interact with the human body.

Smaller, mobile PFAS molecules are more likely to persist, migrate through water systems, and accumulate in living organisms. These are the compounds most commonly associated with environmental contamination and health concerns.

In contrast, larger PFAS molecules—such as fluoropolymers—are designed for stability. These materials are widely used in medical devices and critical applications where durability, chemical resistance, and biostability are required. Due to their size and structure, they are generally not able to cross cell membranes and are considered significantly less likely to pose the same biological risks.2

Understanding this distinction is essential. Treating all PFAS as identical can lead to misinformed decisions, particularly in regulated environments where material performance and safety must be balanced.

PFAS in Food and Water: How the FDA and EPA Regulate Exposure

Regulatory agencies are actively monitoring PFAS across key exposure pathways—most notably in food and water—to better understand and manage risk.

In the food supply, the U.S. Department of Agriculture (USDA) and the U.S. Food and Drug Administration (FDA) have conducted extensive testing. Over several years, 3,199 meat and poultry samples were analyzed, with less than 0.1% testing positive for PFAS. Additional FDA testing of nearly 800 food samples found no detectable PFAS in approximately 97% of cases. When PFAS were detected, they were primarily associated with seafood, where environmental exposure is more likely.1

These findings highlight an important reality: while PFAS contamination can occur, it is not uniformly present across the food system and often depends on environmental conditions, such as water quality and sourcing.

In water, regulation has become more defined. The EPA’s 2024 MCLs establish enforceable limits for specific PFAS compounds in drinking water, marking a significant step toward standardized national oversight.³ These limits are designed to reduce long-term exposure risks and provide clear guidance for municipalities, utilities, and regulated industries.

Together, these efforts reflect a broader shift toward pathway-specific risk management—recognizing that exposure through water, food, and industrial use must be evaluated differently.

Why This Matters for Decision-Makers

PFAS are not a single risk—they are a category of materials with varying properties, applications, and regulatory considerations.

For EHS, compliance, and procurement leaders, the focus should move beyond broad assumptions and toward a more informed evaluation of:

  • Exposure pathways (where risk actually occurs)
  • Material type (small-molecule vs. fluoropolymer)/li>
  • Regulatory oversight (what is restricted vs. what is permitted)

While certain PFAS are being restricted due to environmental persistence and potential health impacts, others remain essential in regulated applications where performance, safety, and durability cannot be compromised.
Understanding these differences is critical to making decisions that are both compliant and operationally effective. For a deeper look at how PFAS claims are validated, read our breakdown of why PFAS-free isn’t just a claim—it’s a process.

Take the Next Step

Understanding material composition and regulatory alignment is critical when evaluating products used in controlled environments. If you’re assessing PFAS-related risk in your operation, contact our team to explore validated, compliant solutions.

About SW Sustainability Solutions

At SW, we are committed to leading the glove industry in environmental, social, and governance (ESG) practices. Our innovative EcoTek® technology exemplifies our dedication to sustainable solutions, while our expertise in sweat management ensures comfort and performance. We also offer specialized chemical compatibility support, assisting customers in selecting gloves tailored to their unique needs. Our mission is to provide products that prioritize safety, health, and environmental responsibility for our customers and the planet

References

  1. U.S. Department of Agriculture (USDA) & U.S. Food and Drug Administration (FDA) — PFAS Food Testing Data
  2. U.S. Food and Drug Administration (FDA) — PFAS in Medical Devices and Health Assessment
  3. U.S. Environmental Protection Agency (EPA) — PFAS National Primary Drinking Water Regulation (2024)